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Allele : Tg(tetO-ERBB2*)26Kkw transgene insertion 26, Kwok-Kin Wong

Primary Identifier  MGI:5912483 Allele Type  Transgenic
Attribute String  Inducible, Inserted expressed sequence Gene  Tg(tetO-ERBB2*)26Kkw
Strain of Origin  FVB/N Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  Seven direct repeats of the tetracycline-operator (tetO) sequence drive inducible expression of the human gene with in-frame AYVM insertion at residue M774 (YVMA used because M774insAYVM and A775insYVMA lead to identical amino acid changes). Two founders were established: 26 (low copy number, high expression levels) and 5B (high copy numbers, low expression levels).
  • mutations:
  • Insertion
  • synonyms:
  • tet-op-hHER2<YVMA>,
  • tet-op-hHER2<YVMA>
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories