Primary Identifier | MGI:5912483 | Allele Type | Transgenic |
Attribute String | Inducible, Inserted expressed sequence | Gene | Tg(tetO-ERBB2*)26Kkw |
Strain of Origin | FVB/N | Induced With | doxycycline/tetracycline |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Seven direct repeats of the tetracycline-operator (tetO) sequence drive inducible expression of the human gene with in-frame AYVM insertion at residue M774 (YVMA used because M774insAYVM and A775insYVMA lead to identical amino acid changes). Two founders were established: 26 (low copy number, high expression levels) and 5B (high copy numbers, low expression levels). |