| Primary Identifier | MGI:5910771 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Tnnt2 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The autosomal dominant Arg141Trp (R141W) mutation found in a family with dilated cardiomyopathy was introduced into exon 9 followed by a floxed neo/zeo cassette via homologous recombination. The neo/zeo cassette was removed via cre-mediated recombination. Reverse transcription-PCR and sequencing of total cardiac RNA confirmed expression of mutant mRNA. |
