Primary Identifier | MGI:5908815 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inducible, Inserted expressed sequence | Gene | Tg(tetO/Prnp-MAPT)769Tli |
Strain of Origin | (C57BL/6 x SJL)F2 | Induced With | doxycycline/tetracycline |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The transgenic construct contains sequence encoding a four-repeat domain of human MAPT protein (TauRD, Q244-E372) under the control of the mouse Prnp gene promoter and the tetO, tetracycline-responsive regulatory element (from the moPrP-tetP vector, 42-bp tet operator sequence copies followed by the constitutively active, minimal human cytomegalovirus promoter). |