| First Author | Saurer L | Year | 2017 |
| Journal | Sci Rep | Volume | 7 |
| Issue | 1 | Pages | 14870 |
| PubMed ID | 29093489 | Mgi Jnum | J:257271 |
| Mgi Id | MGI:6110523 | Doi | 10.1038/s41598-017-14516-4 |
| Citation | Saurer L, et al. (2017) TREM-1 promotes intestinal tumorigenesis. Sci Rep 7(1):14870 |
| abstractText | Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune responses. Increasing evidence suggests a role for TREM-1 not only in acute pathogen-induced reactions but also in chronic and non-infectious inflammatory disorders, including various types of cancer. Here, we demonstrate that genetic deficiency in Trem1 protects from colorectal cancer. In particular, Trem1 (-/-) mice exhibited reduced tumor numbers and load in an experimental model of inflammation-driven tumorigenesis. Gene expression analysis of Trem1 (-/-) versus Trem1 (+/+) tumor tissue demonstrated distinct immune signatures. Whereas Trem1 (-/-) tumors showed an increased abundance of transcripts linked to adaptive immunity, Trem1 (+/+) tumors were characterized by overexpression of innate pro-inflammatory genes associated with tumorigenesis. Compared to adjacent tumor-free colonic mucosa, expression of Trem1 was increased in murine and human colorectal tumors. Unexpectedly, TREM-1 was not detected on tumor-associated Ly6C(-) MHC class II(+) macrophages. In contrast, TREM-1 was highly expressed by tumor-infiltrating neutrophils which represented the predominant myeloid population in Trem1 (+/+) but not in Trem1 (-/-) tumors. Collectively, our findings demonstrate a clear role of TREM-1 for intestinal tumorigenesis and indicate TREM-1-expressing neutrophils as critical players in colorectal tumor development. |
