| Primary Identifier | MGI:5911095 | Allele Type | Targeted |
| Attribute String | Conditional ready, Null/knockout | Gene | Optn |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site and FRT flanked neo cassette was inserted in intron 11, an Asp to Asn mutation was introduced at position 477 in exon 12, and a loxP site was inserted in intron 12 via homologous recombination. Flp-mediated recombination removed the neo cassette. The mutant protein is expressed at higher levels than the wild-type protein and is unable to bind Lys-63-linked polyubiquitin chains. |
