| Primary Identifier | MGI:5909317 | Allele Type | Targeted |
| Attribute String | Not Specified | Gene | Mpz |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A single point mutation (C>T) was engineered in exon 3, changing arginine codon 98 into a cysteine codon (p.Arg98Cys). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 3 was removed through cre-mediated recombination. This mutation emulates a mutation found in some human early onset Charcot-Marie-Tooth disease type 1B (CMT1B) patients. |
