| Primary Identifier | MGI:5909327 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Myh6-Tnni3*R146G)133Rbns |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The murine alpha-myosin heavy chain promoter drives the expression of the mouse troponin I with an arginine to glycine substitution at residue 146 (R146G) in the inhibitory domain which corresponds to the R145G mutation in familial hypertrophic cardiomyopathy in humans. Four lines were generated and two, lines 121 and 133, were analyzed. RNA overexpression levels for line 133 is 3.5-fold higher compared to endogenous RNA. |
