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Allele : Tg(Myh6-Tnni3*R146G)133Rbns transgene insertion 133, Jeffrey Robbins
Primary Identifier  MGI:5909327 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Myh6-Tnni3*R146G)133Rbns
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The murine alpha-myosin heavy chain promoter drives the expression of the mouse troponin I with an arginine to glycine substitution at residue 146 (R146G) in the inhibitory domain which corresponds to the R145G mutation in familial hypertrophic cardiomyopathy in humans. Four lines were generated and two, lines 121 and 133, were analyzed. RNA overexpression levels for line 133 is 3.5-fold higher compared to endogenous RNA.
  • mutations:
  • Insertion
  • synonyms:
  • TnI<146Gly>,
  • TnI<146Gly>
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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