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Allele : Tg(Myh6/tetO-Mybpc3*)#Rbns transgene insertion, Jeffrey Robbins

Primary Identifier  MGI:5909970 Allele Type  Transgenic
Attribute String  Inducible, Inserted expressed sequence Gene  Tg(Myh6/tetO-Mybpc3*)#Rbns
Strain of Origin  Not Specified Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  This transgene contains a 40-kDa N-terminal fragment of Mybpc3 (amino acids 1-271, containing the C0 domain, a Pro/Ala-rich region, the C1 domain, and 17 residues of the M domain) under the transcriptional control of a mouse alpha-myosin heavy chain promoter fused to the tetracycline-response element (tetO). An N-terminal c-myc tag encoding the human c-myc peptide was inserted after the initiation methionine codon to differentiate transgenic protein from the endogenous one. Some leakage in the expression of the 40-kDa fragment is seen. Multiple lines were generated, however the pound (#) symbol is used because line number is not specified.
  • mutations:
  • Insertion
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories