| First Author | Sato T | Year | 1994 |
| Journal | Eur J Immunol | Volume | 24 |
| Issue | 7 | Pages | 1512-6 |
| PubMed ID | 8026513 | Mgi Jnum | J:19310 |
| Mgi Id | MGI:67487 | Doi | 10.1002/eji.1830240708 |
| Citation | Sato T, et al. (1994) Naive T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice. Eur J Immunol 24(7):1512-6 |
| abstractText | We produced transgenic mice expressing T cell receptor-alpha beta chain genes, derived from the chicken ovalbumin (OVA)-specific I-Ad-restricted CD4+CD8- T helper cell clone 7-3-7. In transgenic mice with H-2d genetic background (Tg-d mice), delayed-type hypersensitivity (DTH) was induced in the hind footpad by one inoculation with OVA without any previous sensitization, suggesting that naive T cells have the potential to be involved in DTH response. Spleen cells from nonimmunized Tg-d mice showed a strong T cell proliferative response to in vitro stimulation with OVA. Furthermore, these spleen cells produce cytokines including interleukin(IL)-2, IL-3, interferon-gamma, granulocyte/macrophage colony-stimulating factor, macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, which may play an important role in the attraction of mononuclear cells to an antigen-challenging site. |
