| First Author | Soares F | Year | 2013 |
| Journal | Innate Immun | Volume | 19 |
| Issue | 4 | Pages | 438-48 |
| PubMed ID | 23212541 | Mgi Jnum | J:257411 |
| Mgi Id | MGI:6120909 | Doi | 10.1177/1753425912467383 |
| Citation | Soares F, et al. (2013) NLRX1 does not inhibit MAVS-dependent antiviral signalling. Innate Immun 19(4):438-48 |
| abstractText | NLRX1 is a member of the Nod-like receptor family of intracellular sensors of microbial- and danger-associated molecular patterns. NLRX1 has a N-terminal mitochondrial addressing sequence that localizes the protein to the mitochondrial matrix. Recently, conflicting reports have been presented with regard to the putative implication of NLRX1 as a negative regulator of MAVS-dependent cytosolic antiviral responses. Here, we generated a new NLRX1 knockout mouse strain and observed that bone marrow-derived macrophages and murine embryonic fibroblasts from NLRX1-deficient mice displayed normal antiviral and inflammatory responses following Sendai virus infection. Importantly, wild type and NLRX1-deficient mice exhibited unaltered antiviral and inflammatory gene expression following intranasal challenge with influenza A virus or i.p. injection of Poly (I:C). Together, our results demonstrate that NLRX1 does not participate in the negative regulation of MAVS-dependent antiviral responses. |
