Primary Identifier | MGI:6111410 | Allele Type | Targeted |
Attribute String | Inserted expressed sequence | Gene | Phox2a |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A cDNA for rat Asic2 harboring a G430F mutation was inserted between the first and second exon of the gene, preceded by a floxed EGFP-Neo-STOP-IRES cassette, itself preceded by a splice acceptor site. Upon Cre-mediated recombination the mutant rat Asic2, encoding a toxic allele of the sodium channel, is transcribed from the endogenous promoter. |