| Primary Identifier | MGI:6113870 | Allele Type | Chemically induced (ENU) |
| Attribute String | Modified isoform(s) | Gene | Casp8 |
| Inheritance Mode | Recessive | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | Beutler Mutagenetix |
| molecularNote | ENU-induced T to C transition at base pair 58,844,770 (GRCm38) on chromosome 1, or base pair 49,543 in the GenBank genomic region NC_000067 encoding caspase-8. The mutation corresponds to residue 1,628 in the mRNA sequence NM_009812, within 8 of 9 exons. The mutation results in a valine to alanine substitution at position 432 (V432A) in isoform 1. |
