Primary Identifier | MGI:6107688 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Thap1 |
Transmission | Germline | Strain of Origin | 129S/SvEv |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 2. The neo cassette was removed through subsequent flp-mediated recombination, leaving exon 2 floxed. A G>A substitution was engineered in exon 2, but the exon was deleted through subsequent cre-mediated recombination. |