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Allele : Tg(Pcp2-ATXN1*82Q*V591A*S602D)1BHorr transgene insertion 1B, Harry T Orr
Primary Identifier  MGI:6113692 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Pcp2-ATXN1*82Q*V591A*S602D)1BHorr
Strain of Origin  FVB/N Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene consists of a mouse Pcp2 promoter driving the expression of a human ATXN1 (SCA1) cDNA with 82 CAG repeats and a valine to alanine change at amino acid 591 (V591A) and serine to aspartic acid at posistion 602 (S602D). This is the high expressing line. The Pcp2 promoter targets transgene expression to Purkinje cells.
  • mutations:
  • Insertion
  • synonyms:
  • PCP2-ATXN1[82Q]V591A;S602D,
  • PCP2-ATXN1[82Q]V591A;S602D
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

1 Driven By

3 Publication categories





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