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Allele : Pptc7<em2Pagd> PTC7 protein phosphatase homolog; endonuclease-mediated mutation 2, David J Pagliarini

Primary Identifier	MGI:6143811	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Pptc7
Strain of Origin	C57BL/6J	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR targeting created a substitution of 3 bases (CGA to TCC) followed by a 1 base pair deletion (A) within exon 3 causing a frameshift.

mutations:
Intragenic deletion,
Nucleotide substitutions

synonyms:
Pptc7<em2Pag>,
Pptc7<em2Pag>,
Pptc7E3d1,
Pptc7E3d1

earliestPublication:
Niemi NM, et al. (2019) Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis. Nat Commun 10(1):3197

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

3 Publication categories

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