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Allele : Sox3<em1(Sox2)Pqt> SRY (sex determining region Y)-box 3; endonuclease-mediated mutation 1, Paul Q Thomas

Primary Identifier	MGI:6116390	Allele Type	Endonuclease-mediated
Attribute String	Inserted expressed sequence, Null/knockout	Gene	Sox3
Strain of Origin	C57BL/6N	Is Recombinase	false
Is Wild Type	false

molecularNote

The open reading frame of the gene was replaced with the Sox2 open reading frame. RT-PCR confirmed elevated expression of Sox2 in hemizygous embryos.

mutations:
Insertion,
Intragenic deletion

synonyms:
Sox3<Sox2KI>,
Sox3<Sox2KI>

earliestPublication:
Adikusuma F, et al. (2017) Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes. Genetics 206(3):1495-1503

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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