| Primary Identifier | MGI:6144248 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Eno2-MMP9*)EPfzr |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgenic construct contains a rat enolase 2, gamma neuronal (Eno2) promoter, containing a random filler sequence and an SV40 polyadenylation signal, directing expression of human matrix metallopeptidase 9 (MMP9) cDNA. The MMP9 gene was modified to harbor a glycine to leucine mutation at residue 100 (MMP9*G100L), in the cysteine switch autoinhibitor region, rendering the enzyme constitutively active. Of the five lines, founder line exhibits the highest transgene activity. |
