| Primary Identifier | MGI:6149500 | Allele Type | Targeted |
| Attribute String | Conditional ready, Humanized sequence | Gene | Kras |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The targeting vector is designed to insert a loxP site flanked STOP cassette into intron 1. Exon 4 was modified to change alanine codon 146 to threonine (p.A146T), a mutation commonly found in patients with cancers of the gastrointestinal tract and blood. An FRT site flanked neomycin resistance gene cassette is placed into intron 4. Flp-mediated recombination removed the neo cassette. |
