| First Author | Abe H | Year | 2018 |
| Journal | Science | Volume | 360 |
| Issue | 6384 | Pages | 50-57 |
| PubMed ID | 29622647 | Mgi Jnum | J:260522 |
| Mgi Id | MGI:6150182 | Doi | 10.1126/science.aao2300 |
| Citation | Abe H, et al. (2018) CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage. Science 360(6384):50-57 |
| abstractText | Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found that a small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration of motor function recovery after motor cortex cryoinjury in mice in a training-dependent manner through cortical reorganization. Edonerpic bound to collapsin-response-mediator-protein 2 (CRMP2) and failed to augment recovery in CRMP2-deficient mice. Edonerpic maleate enhanced motor function recovery from internal capsule hemorrhage in nonhuman primates. Thus, edonerpic maleate, a neural plasticity enhancer, could be a clinically potent small compound with which to accelerate rehabilitation after brain damage. |
