| Primary Identifier | MGI:6153137 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Nf1 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Glycin codon 850 (CGT) in exon 21 was changed to arginine (CGT) (p.G850R) and an FRT site flanked neomycin selection cassette was inserted into intron 20. Flp-mediated recombination removed the selection cassette. The mutation recapitulates the human c.2542G>C p.Gly848Arg variant associated with Neurofibromatosis type 1 (NF1). |
