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Allele : Sort1<tm1.1Geno> sortilin 1; targeted mutation 1.1, Genoway

Primary Identifier	MGI:6155012	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Sort1
Transmission	Germline	Strain of Origin	C57BL/6
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was inserted upstream of exon 14 and a FRT-flanked neomycin selection cassette and a second loxP site were inserted downstream of exon 14. Flp-mediated recombination removed the selection cassette, leaving exon 14, encoding part of the beta-propeller domain, floxed.

mutations:
Insertion

cellLines:
Not Specified

earliestPublication:
Goettsch C, et al. (2016) Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest 126(4):1323-36

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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