| Primary Identifier | MGI:6154153 | Allele Type | Targeted |
| Attribute String | Conditional ready, Null/knockout | Gene | Sox10 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The complete open reading frame for the Sox10 Q377X variant was inserted into exon 3 in such a way that the translation start for the mutant is at the wild-type position, and replaced all wild-type sequences (exons 3-5) behind the translation start. In addition, a floxed neomycin cassette was inserted into intron 2, which causes premature termination of transcription and prevents protein production. Immunohistochemistry confirmed absence of protein in E12.5 embryos. |
