| Help | About | Contact Us

Allele : Oas2<M1Apb> 2'-5' oligoadenylate synthetase 2; mutation 1, Australian Phenomics Facility

Primary Identifier	MGI:6154625	Allele Type	Chemically induced (ENU)
Attribute String	Null/knockout	Gene	Oas2
Inheritance Mode	Dominant	Strain of Origin	C57BL/6J
Is Recombinase	false	Is Wild Type	false

molecularNote

An ENU-induced point mutation in conserved codon 405 alters the encoded amino acid from isoleucine to asparagine (p.Ile405Asn or p.I405N). This substitution is in a conserved region of the catalytic domain of the encoded peptide.

mutations:
Single point mutation

synonyms:
Oas2 (I405N),
Oas2 (I405N)

earliestPublication:
Oakes SR, et al. (2017) A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation. PLoS Genet 13(11):e1007072

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=76627720

MouseMine