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Allele : Klhl31<em1Eno> kelch-like 31; endonuclease-mediated mutation 1, Eric N Olson

Primary Identifier  MGI:6163749 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Klhl31
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 technology generated a 2-bp insertion (AT) in exon 2 that creates an in-frame early TAA stop codon 386 bp downstream of the ATG. qRT-PCR of quadriceps shows a significant reduction in transcript level and Western blot analysis shows loss of protein in skeletal muscle of homozygotes.
  • mutations:
  • Insertion
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories