Primary Identifier | MGI:6156948 | Allele Type | Targeted |
Attribute String | Conditional ready, Hypomorph | Gene | Auts2 |
Transmission | Germline | Strain of Origin | C57BL/6N |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP site was inserted upstream of exon 8 and a loxP site and a FRT-flanked neomycin cassette were inserted downstream of exon 8 in opposite orientation. Immunohistochemistry indicates that both the full-length and shorter splicing variant (variant 1 with transcriptional start site in exon 7) proteins are almost completely eliminated in the brain of homozygotes. |