| Primary Identifier | MGI:6156950 | Allele Type | Targeted |
| Attribute String | Modified isoform(s) | Gene | Auts2 |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site was inserted upstream of exon 8 and a loxP site and a FRT-flanked neomycin cassette were inserted downstream of exon 8 in opposite orientation. Cre-mediated recombination removed exon 8 and the selection cassette in germline. The full-length protein is completely eliminated in homozygous brain, however expression of a short isoform (variant 2 with transcriptional start site in exon 9) is increased. |
