| Primary Identifier | MGI:6251554 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Igh |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The knock-in contruct inserted downstream of the Emu enhancer contains a VH promoter driving B cell expression of the cDNA fusion of the 5' end of human PAX5 (exons 1 through 7) with the coding sequence of human ENL (exons 2 through 33). This fusion is present in B cell acute lymphoblastic leukemia with the translocation t(7;9)(q11;p13). Cre-mediated recombination removed the floxed neomycin resistance cassette. |
