| Primary Identifier | MGI:6157962 | Allele Type | Endonuclease-mediated |
| Attribute String | Dominant negative | Gene | Tcf4 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology was used to introduce a single point mutation, an A-to-T transition at position 1135, resulting in an arginine to tryptophan mutation at amino acid 579 (R579W) that corresponds to the most common Pitt-Hopkins Syndrome mutation in humans R580W. |
