| First Author | Kuroda M | Year | 2023 |
| Journal | J Infect Dis | Volume | 228 |
| Issue | Suppl 7 | Pages | S514-S521 |
| PubMed ID | 37562033 | Mgi Jnum | J:360433 |
| Mgi Id | MGI:7780329 | Doi | 10.1093/infdis/jiad325 |
| Citation | Kuroda M, et al. (2023) An Antiviral Role for TRIM14 in Ebola Virus Infection. J Infect Dis 228(Suppl 7):S514-S521 |
| abstractText | Ebola virus (EBOV) is a highly pathogenic virus that encodes 7 multifunctional structural proteins. Multiple host factors have been reported to interact with the EBOV proteins. Here, we found that tripartite motif-containing 14 (TRIM14), an interferon-stimulated gene that mediates cellular signaling pathways associated with type I interferon and inflammatory cytokine production, interacts with EBOV nucleoprotein to enhance interferon-beta (IFN-beta) and nuclear factor-kappaB (NF-kappaB) promotor activation. Moreover, TRIM14 overexpression reduced viral replication in an infectious but biologically contained EBOVDeltaVP30 system by approximately 10-fold without affecting viral protein expression. Furthermore, TRM14-deficient mice were more susceptible to mouse-adapted EBOV infection than wild-type mice. Our data suggest that TRIM14 is a host factor with anti-EBOV activity that limits EBOV pathogenesis. |
