| Primary Identifier | MGI:6194707 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Ttr |
| Transmission | Germline | Strain of Origin | C57BL/6N-A<tm1Brd> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 3 containing a G to C point mutation at the 107th base resulting in a glycine to arginine change at amino acid 83 (Gly83Arg) was introduced into the gene via homologous recombination. A FRT-flanked PGK-neo cassette and a loxP site were inserted upstream of exon 3. Flp-mediated recombination removed the selection cassette. Western blot analysis indicates lower protein expression than in wild-type mice. |
