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Allele : Tmem119<em1(cre/ERT2)Gfng> transmembrane protein 119; endonuclease-mediated mutation 1, Guoping Feng
Primary Identifier  MGI:6195002 Allele Type  Endonuclease-mediated
Attribute String  Inducible, Recombinase Gene  Tmem119
Strain of Origin  C57BL/6NTac Induced With  tamoxifen
Is Recombinase  true Is Wild Type  false
molecularNote  The allele was created using CRISPR/cas9 endonuclease-mediated genome editing to target the stop codon of the transmembrane protein 119 locus (Tmem119) on chromosome 5. The cas9-RNP complex and a 2A-CreERT2 dsDNA (encoding a viral 2A oligopeptide that mediates ribosomal skipping and the CreER fusion gene with ~1.5 kbp homology arms were injected into the pronucleus of C57BL/6NTac mouse embryos. Founders were bred to C57BL/6J mice for germline transmission.
  • mutations:
  • Insertion
  • synonyms:
  • Tmem119-CreERT2,
  • Tmem119-CreERT2
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