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Allele : Col1a1<tm1(CAG-EGFR*T790M*C797S*L858R)Mje> collagen, type I, alpha 1; targeted mutation 1, Michael J Eck
Primary Identifier  MGI:6256800 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence Gene  Col1a1
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Is Recombinase  false Is Wild Type  false
molecularNote  The CAG promotor, a loxP-flanked STOP cassette (LSL) and the human EGFR cDNA with the L858R, the T790M, and the C797S mutations were inserted into the locus. Upon cre-mediated recombination, the STOP cassette is excised promoting expression of the mutant EGFR.
  • mutations:
  • Insertion
  • synonyms:
  • LSL-EGFR T790M/L858R/C797S,
  • TLCS,
  • LSL-EGFR T790M/L858R/C797S,
  • TLCS
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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