| First Author | Xu Y | Year | 2004 |
| Journal | Cancer Res | Volume | 64 |
| Issue | 10 | Pages | 3371-5 |
| PubMed ID | 15150086 | Mgi Jnum | J:90252 |
| Mgi Id | MGI:3042756 | Doi | 10.1158/0008-5472.CAN-04-0044 |
| Citation | Xu Y, et al. (2004) The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia. Cancer Res 64(10):3371-5 |
| abstractText | HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in transformation has not been established. We generated transgenic mice with HMG-I targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene and suggest that it contributes to the pathogenesis of leukemia and other cancers with increased HMG-I expression. |
