| Primary Identifier | MGI:6258385 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Null/knockout | Gene | Pkd1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The codon for leucine 4122 in exon 45 was deleted and a loxP site flanked neomycin resistance gene cassette was inserted into intron 45. The neo cassette was removed through subsequent cre-mediated recombination. The deletion mimics the p.Leu4132Del mutation in some human autosomal dominant polycystic kidney disease (ADPKD) patients. The mutation is in the crucial G protein binding domain and creates a functional knock-out. |
