Primary Identifier | MGI:6258757 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Crbn |
Transmission | Germline | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting vector contains an FRT- and loxP-flanked neomycin cassette inserted upstream of exon 11 followed by a point mutation substitution isoleucine for the corresponding human residue, valine (I391V) in exon 11. Flp-mediated recombination removed the FRT-flanked neo cassette. |