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Allele : Ezh2<em1Jbn> enhancer of zeste 2 polycomb repressive complex 2 subunit; endonuclease-mediated mutation 1, Jeffrey Baron
Primary Identifier  MGI:6259828 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Ezh2
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 technology using guide RNA (CCCCAGCCTGCCACATCAGACGG), SpCas9, and a 127 bp ssODN template introduce a c.1876 G-to-A transversion (NM_004456.4). The resultant GTG to ATG bp (p.V626M) substitution in exon 16 of the gene is confirmed through sequencing.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Ezh2(V626M),
  • Ezh2(V626M)
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

3 Publication categories





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