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Allele : Gt(ROSA)26Sor<tm1.1(HEXB*R505Q)Clk> gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Lorne A Clarke
Primary Identifier  MGI:6260149 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  The human HEXB (hexosaminidase B) gene and human growth hormone polyA sequences followed by a loxP-flanked neomycin cassette are inserted into intron 1 of Gt(ROSA)26Sor placing HEXB expression under the control of the ROSA26 promoter. HEXB is modified by site-directed mutagenesis to harbor an arginine to glutamine mutation at residue 505 (R505Q). Cre-mediated recombination removed the floxed neo cassette.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • hHEXB R505Q,
  • hHEXB R505Q
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

3 Publication categories





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