| First Author | Steidl JV | Year | 2003 |
| Journal | Neuroreport | Volume | 14 |
| Issue | 2 | Pages | 219-23 |
| PubMed ID | 12598733 | Mgi Jnum | J:89837 |
| Mgi Id | MGI:3041732 | Doi | 10.1097/00001756-200302100-00012 |
| Citation | Steidl JV, et al. (2003) Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic mice. Neuroreport 14(2):219-23 |
| abstractText | Hippocampal synaptic plasticity was studied in transgenic mice over-expressing human alpha-synuclein containing the A30P Parkinson's disease mutation. Medial perforant path-dentate granule cell synapses showed enhanced paired-pulse depression (PPD) for short interpulse intervals (< 200 ms), without differences in basal transmission. Extracellular calcium reduction failed to rescue the enhanced PPD. Paired-pulse facilitation in the CA1 region was normal in slices from transgenic mice, but enhanced synaptic depression was revealed upon repetitive stimulation of the Schaffer collaterals. Long-term potentiation in the CA1 field was not impaired in slices from transgenic mice. These results suggest that mutant alpha-synuclein accumulation impairs short-term changes in synaptic strength when neurotransmitter availability is limited due to enhanced release probability or repetitive synaptic activity. |
