| Primary Identifier | MGI:6314594 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Ttbk2 |
| Inheritance Mode | Not Specified | Strain of Origin | C57BL/6NJ |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | IMPC |
| molecularNote | This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TGAGGGAAAGAGTAAATCAA and GACGGTTCCTTCAGAATCCA, which resulted in a 364 bp deletion beginning at Chromosome 2 position 120,760,099 bp and ending after 120,760,462 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001306611 (exon 11) and 206 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 343 and early truncation 17 amino acids later. |
