| Primary Identifier | MGI:6273307 | Allele Type | Targeted |
| Attribute String | Constitutively active | Gene | Lrrk2 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 41 was replaced with one containing GGG to TCA nucleotide substitutions which results in a glycine to serine change at amino acid 2019 (G2019S). A loxP and frt-flanked PGK-neomycin cassette were inserted into intron 41 and another loxP site was inserted in intron 42. Flp-mediated recombination removed the neomycin cassette. This is a gain-of-kinase function mutation. |
