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Allele : Tg(LCR-HBG2,-HBG1)1352Hhb transgene insertion 1352, Henny Billett
Primary Identifier  MGI:6277094 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(LCR-HBG2,-HBG1)1352Hhb
Strain of Origin  (C57BL/6 x SJL)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  The human beta globin cluster is modified such that the locus control region (LCR) consisting of 4 DNAse I hypersensitive site (HS4-1) is inserted upstream of HBG2, HBG1, and the HBBP1 pseudogene. Founder line 1352 was established. Expression of the HBG2 gene is 3-7 fold higher than the HBG1 gene in embryonic and fetal erythroid cells.
  • mutations:
  • Insertion
  • synonyms:
  • LCR <G>gamma <A>gamma psi beta,
  • LCR <G>gamma <A>gamma psi beta
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

3 Publication categories





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