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Allele : Trem2<em3Bwef> triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 3, Benedikt Wefers
Primary Identifier  MGI:6295472 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Trem2
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9-mediated homologous recombination using a synthetic oligodeoxynucleotide created a nucleotide substitution (C to T) in exon 3 of Trem2 that results in the amino acid substitution H157Y. Two additional silent nucleotide exchanges within the protospacer/PAM region created an ApaLI restriction site for genotyping purposes.
  • mutations:
  • Single point mutation
  • synonyms:
  • Trem2<em3(H157Y)Bwef>,
  • Trem2(H157Y),
  • Trem2 p.H157Y,
  • Trem2<em3(H157Y)Bwef>,
  • Trem2 p.H157Y,
  • Trem2(H157Y)
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

1 Publication categories





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