| Primary Identifier | MGI:6286495 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Myoc*Y423H)#Sit |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene consists of BAC DNA 16652 containing the full-length mouse myocilin with a Tyr423His point mutation (T to C in codon 423) as well as 20 and 85.5 kb of the 5'-flanking and 3'-flanking sequences. This mutation corresponds to the severe glaucoma-causing Tyr437His mutation in human. Several lines were generated, however one line containing 2-3 copies of the mutated gene was used for analysis. The pound symbol (#) is used when line is not specified. |
