| Primary Identifier | MGI:6284017 | Allele Type | Chemically induced (ENU) |
| Attribute String | Not Specified | Gene | Nlrp3 |
| Inheritance Mode | Recessive | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | Beutler Mutagenetix |
| description | https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3795 |
| molecularNote | ENU-mutagenesis induced an A to T transversion at base pair 59,558,448 (v38) on chromosome 11, or base pair 16,880 in the GenBank genomic region NC_000077. The mutation corresponds to residue 2,781 in the mRNA sequence NM_145827 within exon 7 of 10 total exons. The mutated nucleotide is indicated in red. The mutation results in a histidine to leucine substitution at position 852 (H852L) in the NLRP3 protein. |
