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Allele : Vav1<M5Btlr> vav 1 oncogene; mutation 5, Bruce Beutler

Primary Identifier  MGI:6285528 Allele Type  Chemically induced (ENU)
Attribute String  Not Specified Gene  Vav1
Inheritance Mode  Semidominant Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
Project Collection  Beutler Mutagenetix
description  https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3878
molecularNote  ENU-induced A to G transition at base pair 57,301,870 (v38) on chromosome 17, or base pair 22,792 in the GenBank genomic region NC_000083. The mutation corresponds to residue 1,131 in the mRNA sequence NM_011691 within exon 11 of 27 total exons. The mutation results in a lysine to glutamic acid substitution at amino acid 345 (K345E) in the VAV1 protein.
  • mutations:
  • Single point mutation
  • synonyms:
  • Late,
  • Late
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

3 Publication categories