Primary Identifier | MGI:6285528 | Allele Type | Chemically induced (ENU) |
Attribute String | Not Specified | Gene | Vav1 |
Inheritance Mode | Semidominant | Strain of Origin | C57BL/6J |
Is Recombinase | false | Is Wild Type | false |
Project Collection | Beutler Mutagenetix |
description | https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3878 |
molecularNote | ENU-induced A to G transition at base pair 57,301,870 (v38) on chromosome 17, or base pair 22,792 in the GenBank genomic region NC_000083. The mutation corresponds to residue 1,131 in the mRNA sequence NM_011691 within exon 11 of 27 total exons. The mutation results in a lysine to glutamic acid substitution at amino acid 345 (K345E) in the VAV1 protein. |