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Allele : Unc93b1<em1Btlr> unc-93 homolog B1, TLR signaling regulator; endonuclease-mediated mutation 1, Bruce Beutler

Primary Identifier  MGI:6303989 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Unc93b1
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  The CRISPR/Cas9 system and sgRNA 5'-AGGAAGTCCCAACCAGCTGC-3' was used to generate the mice. The CRISPR/Cas9 system generated a 109-base pair deletion at c.138_28del (NM_019449.2). The mutation is predicted to cause a frame-shifted protein product beginning after amino acid 7 of the protein and premature termination after the inclusion of 63 aberrant amino acids.
  • mutations:
  • Intragenic deletion
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories