Primary Identifier | MGI:6336135 | Allele Type | Targeted |
Attribute String | Modified regulatory region | Gene | Rr102 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | An FRT site flanked neomycin resistance cassette and a loxP site flanked chicken transcriptional enhancer element A that contains specific mutations in the Egr2 binding sites that prevent binding of wild-type Egr2 and instead allow binding of a mutant Egr2 protein, and an F3-flanked mouse element A replaced the wild-type Egr2 autoregulatory element A. Flp-mediated recombination removed the F3 flanked mouse element A and the neo cassette and cre-mediated recombination removed the floxed chicken element A. |