| Primary Identifier | MGI:6331299 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inducible, Inserted expressed sequence, Reporter | Gene | Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz |
| Strain of Origin | FVB/N | Induced With | doxycycline/tetracycline |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The human APOL1 kidney disease risk variant G1 contains a double missense mutation resulting in a serine to glycine change at amino acid 342 (S342G) and isoleucine to methionine change at amino acid 384 (I384M) and is able to lyse T. brucei rhodesiense, is under the control of the tetracycline responsive promoter element. The pound (#) sign is used when the line number is not specified or lines are pooled. The gene is only expressed in a tetracycline/doxycycline controllable manner when mice carrying this allele also carry a tTA or rtTA allele. |
